Anti-Cleaved PARP Monoclonal Antibody
應(yīng)用 WB
稀釋比例WB 1:1000-3000.
交叉反應(yīng)Human

產(chǎn)品型號(hào)：K200027M

更新時(shí)間：2022-08-15

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Anti-Cleaved PARP Monoclonal Antibody

英文名稱	Anti-Cleaved PARP Monoclonal Antibody
宿主	Mouse
別名	PARP-1; Poly(ADP ribose) polymerase 1; sPARP1;ADPRT1; ADP ribosyltransferase NAD(+)
應(yīng)用	WB
稀釋比例	WB 1:1000-3000.
交叉反應(yīng)	Human
蛋白分子量	116kDa(Pro)89kDa(Active)
Gene ID	142
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲(chǔ)存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG1
免疫原	A synthetic peptide coupled to KLH
性狀	液體
Public Immunogen Range	A synthetic peptide coupled to KLH
Subcellular Locations	Nucleus
Swiss Prot	P09874
克隆號(hào)	M4
克隆類型	Monoclonal Antibody
背景資料	Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate.