Anti-PCNA Polyclonal Antibody
應(yīng)用 WB
稀釋比例WB 1:500-2000.
交叉反應(yīng)Human Mouse Rat

產(chǎn)品型號：K101310P

更新時間：2022-08-15

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標簽抗體血清球蛋白 IgG Polyclonal Antibody Antibody Monoclonal Antibody 一抗內(nèi)參抗體膠體金標記二抗生物素化二抗 RBITC熒光標記抗體二抗 FITC熒光標記抗體二抗免疫血清二抗純化抗體二抗 HRP標記二抗免疫球蛋白抗原IgG二抗

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Anti-PCNA Polyclonal Antibody

英文名稱	Anti-PCNA Polyclonal Antibody
宿主	Rabbit
別名	ATLD2;cb16;Cyclin;HGCN872;MGC8367
應(yīng)用	WB
稀釋比例	WB 1:500-2000.
交叉反應(yīng)	Human Mouse Rat
蛋白分子量	29kDa
Gene ID	5111
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG
免疫原	A synthetic peptide of human PCNA
性狀	液體
Public Immunogen Range	A synthetic peptide of human PCNA
Subcellular Locations	Nucleus
Swiss Prot	P12004
克隆類型	Polyclonal Antibody
背景資料	Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.