Anti-ITB1 Polyclonal Antibody
應(yīng)用 WB
稀釋比例WB 1:5000.
交叉反應(yīng)Mouse

產(chǎn)品型號：K101537P

更新時間：2022-08-15

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抗體

標簽抗體血清球蛋白 IgG Polyclonal Antibody Antibody Monoclonal Antibody 一抗內(nèi)參抗體膠體金標記二抗生物素化二抗 RBITC熒光標記抗體二抗 FITC熒光標記抗體二抗免疫血清二抗純化抗體二抗 HRP標記二抗免疫球蛋白抗原IgG二抗

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Anti-ITB1 Polyclonal Antibody

英文名稱	Anti-ITB1 Polyclonal Antibody
宿主	Rabbit
別名	AC;ACDase;ASAH;PHP;PHP32;SMAPME
應(yīng)用	WB
稀釋比例	WB 1:5000.
交叉反應(yīng)	Mouse
蛋白分子量	88kDa
Gene ID	16412
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG
免疫原	A synthetic peptide of human ITB1
性狀	液體
Public Immunogen Range	A synthetic peptide of human ITB1
Subcellular Locations	Plasma membrane Endosome
Swiss Prot	P09055
克隆類型	Polyclonal Antibody
背景資料	Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (By similarity). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (By similarity). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity).