Anti-SMAD4 Polyclonal Antibody
應(yīng)用 WB
稀釋比例WB 1:500-2000.
交叉反應(yīng)Human

產(chǎn)品型號：K106621P

更新時間：2022-08-15

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Anti-SMAD4 Polyclonal Antibody

英文名稱	Anti-SMAD4 Polyclonal Antibody
宿主	Rabbit
別名	DPC4;hSMAD4;JIP;MAD homolog 4;MADH4;Mothers against DPP homolog 4;SMAD 4;SMAD family member 4;SMAD4
應(yīng)用	WB
稀釋比例	WB 1:500-2000.
交叉反應(yīng)	Human
蛋白分子量	60kDa
Gene ID	4089
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG
免疫原	Recombinant protein of human SMAD4
性狀	液體
Public Immunogen Range	Recombinant protein of human SMAD4
Subcellular Locations	Cytoplasm Nucleus
Swiss Prot	Q13485
克隆類型	Polyclonal Antibody
背景資料	This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.